【Press Release】Toei Shinyaku Files Patent for King Agaricus KA21 for Improving Male Menopausal Symptoms such as ED and Hair Loss
Posted on July 09 2024,

Expected Applications in Hair Growth, Menopausal Disorders, and ED Recovery Supplements for Men.
【Press Release】
English:https://en.atpress.com/news/401642
日本語:https://www.atpress.ne.jp/news/401642
中文:https://zh.atpress.com/news/401642
Toei Shinyaku Co., Ltd. (Headquarters: Mitaka, Tokyo; CEO: Akitomo Motoi) conducted a joint study with Shigakkan University’s Faculty of Health Sciences on our outdoor-cultivated Agaricus blazei/brasiliensis/subrufescens KA21 strain (hereinafter referred to as King Agaricus KA21). The study confirmed the improvement effects of King Agaricus KA21 intake on male menopausal symptoms such as ED and hair loss. Based on these findings, we are pleased to report that we have filed a patent for "Compositions for Improving Male Menopausal Symptoms such as Hair Loss and ED, and Pharmaceuticals and Food Products Containing These."
Overview
Patent Application Number: 2024-109541
Submission Date: July 8, 2024
Inventors: Hirobumi Tada, Akitomo Motoi
Patent Applicants: Toei Shinyaku Co., Ltd., Shigakkan University
Title of the Invention:
"Compositions for Improving Male Menopausal Symptoms such as ED and Hair loss, and Pharmaceuticals and Food Products Containing These."
Technical Field:
This invention relates to compositions for improving male menopausal symptoms such as ED and hair loss, and pharmaceuticals and food products containing these.
Study Data
24 men aged 50 to 70 were given 900mg of outdoor-cultivated Agaricus KA21 daily for two months, and the indicators related to male menopausal symptoms were compared before and after intake. Significant improvements were observed in AMS (Aging Males Symptoms) scores, indicators for assessing male menopausal symptoms including mental, psychological, and physical aspects, EHS (Erection Hardness) scores for evaluating ED, SHIM (Sexual Health Inventory for Men) scores for male sexual health assessment, and hair loss conditions.
*P < 0.05, ***P < 0.001
About Male Menopausal Symptoms
Testosterone, a male hormone, plays a crucial role in maintaining male physical and mental functions. However, the amount of testosterone gradually decreases with age. External factors such as lifestyle and stress also impact testosterone levels. Decreased testosterone is closely related to conditions such as sarcopenia, which involves muscle loss and muscle weakness, and also affects the causes and prevention of various diseases, including angina, arteriosclerosis, obesity, metabolic syndrome, and dementia. These conditions associated with decreased testosterone are known as Late Onset Hypogonadism (LOH) syndrome. Reports indicate that about 10% of middle-aged men in employment suffer from male menopausal symptoms, with a notable prevalence starting from the late 40s, making LOH a significant social and economic concern.
LOH manifests in a variety of symptoms including general fatigue, decreased libido, lack of motivation, ED, difficulty concentrating, insomnia, irritability, shoulder stiffness, urination problems, a sense of heaviness in the head, and fewer morning erections. Additionally, age-related testosterone decline increases the risk of several health issues such as depression, sexual dysfunction, cognitive decline, cardiovascular diseases, increased visceral fat, insulin resistance, decreased HDL cholesterol, and elevated total cholesterol and LDL cholesterol.