King Agaricus 100 Tablets

In healthy subjects, after oral intake of 9 g of open-pollinated Agaricus KA21 per day (3 to 22 times the standard intake) for 6 months, the product's safety was confirmed with no side effects and no effect on liver and kidney function values.
Source: https://pubmed.ncbi.nlm.nih.gov/18604247/

The safety of open-pollinated Agaricus KA21 was confirmed in a test tube study and an animal study in which 1 g per 1 kg of body weight (approximately 16 to 125 times the standard intake) was ingested.　
Source: https://pubmed.ncbi.nlm.nih.gov/22506574/

According to a survey conducted in Japan using a Ministry of Health, Labour and Welfare (MHLW) cancer research grant, 44.6% of cancer patients used complementary and alternative medicine (CAM). 96.2% of CAM users took supplements, 60.6% chose to take Agaricus.
Source: https://pubmed.ncbi.nlm.nih.gov/15728227/

Natural killer cells, a type of immune cell, were activated in healthy subjects by taking 3 g of open-pollinated Agaricus KA21 per day for one week. *Natural killer cells are immune cells that attack cancer cells and pathogens that cause infections.
Source: https://pubmed.ncbi.nlm.nih.gov/18604247/

Based on the above research results, intake of Agaricus KA21 is thought to enhance immunity and prevent infection.

Mice receiving the anti-cancer drug (5-FU) were fed orally with feed containing open-pollinated Agaricus KA21 and were evaluated for leukopenia, diarrhea, weight loss, feeding disorder, renal disorder, gastrointestinal disorder, and hair loss, which are side effects of the anti-cancer drug.

As a result, the ingestion of open-pollinated Agaricus was confirmed to reduce the side effects of anti-cancer drugs, but not that of house-grown Agaricus. The impact of KA21 on reducing the side effects of anti-cancer drugs may be helpful for the physical condition of cancer patients. The potent antioxidant activity of open-pollinated Agaricus may have reduced the side effects of anti-cancer drugs.
Source: https://pubmed.ncbi.nlm.nih.gov/32463996/

Akkermansia muciniphila, a type of intestinal bacteria, affects the efficacy of immune checkpoint inhibitors.　
Source: https://pubmed.ncbi.nlm.nih.gov/29097494/
* Accumulation of open-pollinated Agaricus KA21 in a mouse study confirmed the growth effect of Bacillus subtilis Ackermansia mussinifera. Japanese patent pending.

When wound model mice were fed orally with feed containing open-pollinated Agaricus KA21, the production of skin collagen type 3 was stimulated, and its wound-healing promoting effect was confirmed. The skin moisturizing effect against dryness was also confirmed in the same study.　
* Presented at the 39th Annual Meeting of the Japanese Society of Aesthetic Dermatology, paper in preparation for submission

When mice with liver inflammation caused by intraperitoneal administration of carbon tetrachloride were orally given feed containing either open-pollinated Agaricus KA21 or house-grown Agaricus KA21, only the group fed with open-pollinated Agaricus KA21 showed a protective effect on the liver.
Source: https://pubmed.ncbi.nlm.nih.gov/25418207/

When healthy people orally ingested 900 to 1500 mg of open-pollinated Agaricus KA21 per day, the effects of reduced fatigue, better awakening (improved sleep quality), reduced stiff shoulders, and improved sensitivity to cold were confirmed after 6 and 12 weeks of ingestion. In addition, when 1500 mg was taken per day, improvement of hair loss and graying was confirmed after 6 weeks and 12 weeks.
Source: https://pubmed.ncbi.nlm.nih.gov/26756293/